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Published: July 22, 2021

The addition of Guanidinoacetic acid (GAA)can significantly increase the creatine

What is Guanidinoacetic acid (GAA)?

GAA, also known as guanidinoacetic acid (GAA), is usually a white powder or flake crystal and is the only precursor for the synthesis of creatine.  

In animals,  guanidinoacetic acid (GAA) is synthesized from L-arginine and glycine and subsequently reaches the liver via blood circulation, where it is catalyzed by S-adenosylmethionine-guanidino acetic acid-N-methyltransferase (GAMT) to form creatine with adenosylmethionine (SAM).  

Creatine can be synthesized as phosphorylated creatine by the action of creatine kinase, which participates in the adenosine triphosphate cycle and plays a very important role in the energy metabolism and growth and development of animals. 

In addition, creatine is also a semi-essential amino acid in animals, which can be synthesized by animals themselves or supplemented by exogenous sources. There are two ways for livestock to obtain creatine, either by endogenous synthesis or by feeding animal protein sources. With the phasing out of animal protein feeds, livestock fed all plant protein-based diets may not meet their daily creatine requirements, creatine synthesis by animals only accounts for 66% to 75% of the body's creatine requirement, and must be supplemented with exogenous sources.  Compared with creatine, guanidinoacetic acid (GAA) is more stable, cheaper, and more suitable to be as a feed additive. It can not only be converted to creatine in the body but also can save L-arginine in the diet as creatine supplementation. The exogenous addition of GAA can significantly increase the tissue creatine level by more than 20%. 

Now, let us find out about some of the benefits of GAA it brings to poultry farmers to help with their farms and animals. While there are many benefits to the application of GAA to animal feed. Only some of the key factors

Benefits of GAA as a feed additive

1. Increase muscle and tissues

GAA helps the muscle and tissue develop faster in poultry animals. Because it will fatten them to a healthier level, so more meat is obtainable by them during the slaughter process. Therefore many poultry farms use guanidinoacetic acid as a fattening agent on their animals.

2. Increase overall growth

And it also helps to increase growth in animals overall not just the muscle and tissues. It indeed helps the muscles and tissues to develop faster. But at the same time, it helps the animal to grow faster in other areas as well.

3. Increase hatch rate

Eggs laid by poultry animals that are fed GAA have a higher hatch rate according to studies. It will make the product delivery process much faster in poultry farms. So the farmers can yield more profits within a short time period.

4. Higher quality in meat

According to research, GAA-fed animals have more quality in their meat than the ones who did not. Helping farmers to obtain the ideal poultry products. Due to these facts, guanidinoacetic acid is considered one of the best feed additives you can find on the market used to increase the quality of poultry products.

5. Reduce costs

GAA is mostly used with a vegetarian diet instead of other protein alternatives. Therefore reducing costs related to the diet of the poultry animals. Because protein diets are a bit expensive than vegetarian ones. And as a farmer, it is wise to choose GAA over other feed additives that require protein diets to be effective.


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